Discount Vitamins & Herbs

   
- Products by Category
- Alphabetic Product Listing

Home Go Shopping Specials Product Info Health News FAQs About Us Links Site Map

Hyaluronic Acid Center, Neptune Krill Oil & Rejuvenation Science for Doctors

HACKER SAFE certified sites prevent over 99.9% of hacker crime.

Health Guide
Men's Health
Women's Health
Senior's Health
Antioxidants
Sports Nutrition
Diet & Weight Loss

Vitamins & Minerals
Herbs
Specialty
Supplements

Targeted
Supplements

Spa Products
Anti-Aging Basics
Body Systems
Body Structure
Book Store
Pet Health

My Recommendation
My Favorite Articles
Our Most Popular
Specials
Bargain Basement
Brands

Free Samples

In-depth Info

MSM


Health News Archive 416 - Huntington's Disease
<<back to structure/function index


Green Tea Extract Slows the Progression of Huntington’s Disease

A new study conducted in vitro and in fruit flies indicates that the green tea polyphenol, epigallocatechin gallate (EGCG), may slow the build up of proteins that are implicated in Huntington’s disease and may slow the motor function decline that occurs in Huntington’s patients.

Huntington's disease is a progressive neurodegenerative disorder for which only symptomatic treatments of limited effectiveness are available. Early symptoms of Huntington's Disease may affect cognitive ability or mobility and
include depression, mood swings, forgetfulness, clumsiness, involuntary twitching and lack of coordination. As the disease progresses, concentration and short-term memory diminish and involuntary movements of the head, trunk and limbs increase. Walking, speaking and swallowing abilities deteriorate. Eventually the person is unable to care
for him or herself.

Huntington’s is a hereditary disease and scientists have discovered the gene that causes proteins to mutate into the huntingtin protein. A mutation in this protein results in elongation of parts of the protein called polyglutamine chains, which cause the overall huntingtin protein to lose its normal structure. The body will not expel these mutant proteins and consequently they build up in the brain, where they are ultimately lethal to nerve cells.

Once the disease has developed it is incurable, so stopping the buildup of damaging proteins as well as stopping the proteins from misfolding could slow or prevent the development of the disease. As of the publication of this preliminary study, the Huntington's Disease Society of America website indicated that "Research has yet to find a means of curing or even slowing the deadly progression of HD although some medications can relieve some of the symptoms in certain individuals."

In the new study, scientists investigated the effects of EGCG from green tea on the aggregation of these mutant proteins in vitro. The study authors discovered that the green tea extract could strongly interfere with the early events leading up to the buildup of mutant proteins in a dose-dependent manner. In vitro, the green tea extract was able to inhibit the misfolding of the proteins.

As part of the same study, the researchers used fruit flies genetically modified to over-express the mutant protein, which served as a model for the hereditary disease. When the green tea extract was fed to the flies, photoreceptor degeneration and motor function improved.

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder for which only symptomatic treatments of limited effectiveness are available. Preventing early misfolding steps and thereby aggregation of the polyglutamine (polyQ)-containing protein huntingtin (htt) in neurons of patients may represent an attractive therapeutic strategy to postpone the onset and progression of HD. Here, we demonstrate that the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) potently inhibits the aggregation of mutant htt exon 1 protein in a dose-dependent manner. Dot-blot assays and atomic force microscopy studies revealed that EGCG modulates misfolding and oligomerization of mutant htt exon 1 protein in vitro, indicating that it interferes with very early events in the aggregation process. Also, EGCG significantly reduced polyQ-mediated htt protein aggregation and cytotoxicity in an yeast model of HD. When EGCG was fed to transgenic HD flies overexpressing a pathogenic htt exon 1 protein, photoreceptor degeneration and motor function improved. These results indicate that modulators of htt exon 1 misfolding and oligomerization like EGCG are likely to reduce polyQ-mediated toxicity in vivo. Our studies may provide the basis for the development of a novel pharmacotherapy for HD and related polyQ disorders.

Source: Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE. Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet. 2006 Sep 15;15(18):2743-51. Epub 2006 Aug 7.

back to top

Featured Products
 
  Green Tea
MSRP:
$11.95
Our price:
$
9.00
 
  Green Tea
Drugstore price: $9.00
Our price:
$
7.00
 
  High Energy Chai Green Tea

Our price:
$
4.00

Benfotiamine - Calcium - Coral Calcium - Ester-C - Folic Acid - Silicon - Strontium - Vitamin A - Vitamin B6 - Vitamin B12 - Vitamin C - Vitamin D - Vitamin E - Vitamin K

5-HTP - 7-Keto DHEA - Acai - Acetyl L-Carnitine  - Ageless Face, Ageless Mind - AHCC - Albizzia - Alpha-Lipoic Acid and R-Lipoic Acid - Aronia from Chokeberry - Astaxanthin - Avemar - Bacopa - Beta Glucan - Bilberry - Bioperine - Butterbur - Cetyl Myristoleate (CMO) - Chlorella: Sun, Yaeyama - Cinnamon - CLA - Coconut Oil - CoEnzymeQ10 - Curcumin from Turmeric - DHA Neuromins - Digestive Enzymes - Echinacea - Epicor -FenugreekFrench Maritime Pine Tree Bark - Garlic - Ginkgo Biloba -Glucosamine & Chondroitin - Goji Berry - Goldenseal - Grape Seed Extract - Green Tea - Guggulow - Hoodia - Horse Chestnut - Human Growth Hormone (HGH) - Hyaluronic Acid - Hydrogen (H-): The Fuel of Life - IP-6 - Krill Oil - Kudzu - L-Arginine - L-CarnitineL-Carnosine - L-Methylfolate - L-Tyrosine - Lutein - Lycopene - Mangosteen - Milk Thistle - Modified Citrus Pectin (MCP) - MSM - Mushrooms - N-Acetyl Cysteine (NAC) - Nattokinase - Neptune Krill Oil - Oil of Oregano - Oligonol - Omega-3 - DHA, EPA - Pepsin GI - Phosphatidyl Serine (PS) - Pinolenic Acid - Policosanol - Pomegranate - Prevagen - Probiotics - Probiotic Bacillus Coagulans - Psyllium Fiber - PycnogenolQuercetin - Red Yeast Rice - ReloraResveratrol - Rhodiola Rosea - Ribose - SAM-e - Saw Palmetto - Shower Water Filter - St. John's Wort - Stevia - Sytrinol - Thymic Protein AUbiquinol - Valerian - Vinpocetine

Age-Related Macular Degeneration - Air Pollution - Albizzia Helps Reduce Anxiety and Stress - Alzheimer Studies - Anxiety & Stress - Attentive Child - ADD, ADHD - Calorie Restriction Diet - Candida - Colon Cancer, Colitis, IBD - COX-2, Ibuprofen Side Effects, and Pain Management - Energy - Enzymes Support Digestion - Erectile Dysfunction - Gray Hair and Balding - Hair Growth and Male Pattern Baldness - Hearing - Homocysteine - Inflammation and Weight Loss - Immune - Life Force Multiple - Liver - Menopause - Men's Fertility - Mercury Cleansing - Milk Thistle and Liver Disease - Minor Pain and Inflammation - Omega-3 - Ultra Purity CO2 vs. Molecular Distillation - ORAC - Osteoporosis - Pain Relief - Parkinson's Disease CoenzymeQ10? - The Perricone Weight-Loss Diet - Relora Cortisol and Stress-Induced Eating - Senior's Health - Side Effects of Lipitor®, Zocor® and Statin Drugs  - The Sinatra Solution: for Heart Disease - Sinus and Allergy - St. John's Wort - Prozac® - Syndrome X - Tinnitus - Transitions for Menopause - Varicose Veins and Spider Veins  - The Wrinkle Cure for Youthful Skin

Home | Specials | Product Info | Old Health News | FAQs | About us | Blog | Links | Links2 | Links3 | Sitemap | Contact us
Alphabetic Product Listing | Products by Category | Links4 | Links5
TOLL FREE: 800-401-9186

View Cart


Terms of Use | Privacy Policy | Terms and Conditions of Sale | Disclaimer

Copyright © 2001-2010, Discount Herbs & Vitamins, Inc. All rights reserved.

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
Please consult a qualified medical practitioner for medical advice.